PRACTICAL 3 : ASSESSMENT OF QUALITY OF TABLETS AND CAPSULES (3)

EXPERIMENT 3: TABLET FRIABILITY

OBJECTIVES

1.      To determine the percentage loss of weight of certain amount of tablets.

2.      To determine the physical strength of tablets upon exposure to mechanical shock or attrition.

INTRODUCTION

       Friability is defined as the percentage of weight loss by tablets due to mechanical action or friction during the test. The initial weights of certain amount of tablets are measured as a whole. Friability refer to the ability of the compressed tablets to avoid fracture and breaking during the transport. It is related to tablet harness and designed to evaluate the ability of tablet to withstand aberration in packing, handling and shipping. It is measured by the use of friability tester.

APPARATUS AND MATERIAL

10 tablets

2 Weighting boats

PROCEDURES:

Process of friablity of tablets

1.      10 tablets were selected and weighted.

2.      All tablets were put into the drums of tablet aberration and friability tester. The rate of rotation was set at 100 rpm for 10 minutes and the operation started.

3.      All the tablets were removed and ensure freedom from dust or powder at the end of operation. The tablets were reweighted. The percentage loss of weight determined.

4.      Compressed tablet should not lose more than 1% of its weight.

RESULT:

	WEIGHT OF 10 TABLETS
Before	5.7752
After	5.7215
Differences	0.0537

DISCUSSION:

       A maximum weight loss should not be more than 1% of the weight of the tablets during friability test. Generally, it is acceptable and any broken or smashed tablets were not picked up. Thus, after calculation we got 0.9298% which is the acceptable one. There are several factors affected if the percentage loss is greater than 1%. Firstly, the tablet may be expired so, the hardness is too low causing it to fracture than normal. Then, there are several changes to the rpm of the machine which is 75rpm. In the lab, the are 2 machine that has 2 different rpm which is 25rpm and 75 rpm. 

CONCLUSION:

     For the conclusion, the percentage of lost that we got is 0.9298% (below than 1%) , which show that the tablets promotes a good behaviour.